Siren Biotechnology

Turning deadly cancers into treatable diseases, backed by Founders Fund

https://wefunder.com/siren.biotechnology

Total raised on Wefunder: 4058119

Total investors: 1503

Quick facts

  • $28M raised from leading VCs including Founders Fund, Lux Capital, and more
  • Fighting the world’s second deadliest disease, cancer, with AAV immuno-gene therapy
  • Led by expert doctors and scientists from Stanford, UCSF, Duke, Mount Sinai, and Roche
  • 2025 Start Up of The Year winner at Phacilitate Advanced Therapies Week
  • $4M in competitive grant awards from the California Institute for Regenerative Medicine (CIRM)
  • Targeting clinical trials in 2026, a critical step toward FDA approval and commercialization
  • The global brain tumor therapeutics market is a $3.2B market
  • CEO featured in The Wall Street Journal, The Economist, WIRED, MIT Tech Review, and Boston Globe

Team profiles

Featured investor profiles

Siren Biotechnology

Turning deadly cancers into treatable diseases, backed by Founders Fund

Investment Terms

You will be investing in Siren Biotechnology through an SPV. This means that when you invest, you will be signing the SPV Subscription Agreement, not the direct investment contract. For more information on SPVs, see here.

Financials

We have financial statements ending December 31, 2025. Our cash in hand is $11,409,190, as of March 2025. Over the three months prior, revenues averaged $0/month, cost of goods sold has averaged $0/month, and operational expenses have averaged $474,000/month.

At a Glance

Jan 1 – Dec 31, 2025
Revenue icon
$0
Revenue
Net loss icon
-$10,884,000
Net Loss
Short-term debt icon
$377,000
-52%
Short-Term Liabilities
Valuation icon
$4,058,119
Raised in 2025
Cash in bank icon
$11,409,190
Cash on Hand
Net Margin:
0%
Gross Margin:
0%
Return on Assets:
-91%
Earnings per Share:
-$0.96
Revenue per Employee:
$0
Cash to Assets:
99%
Revenue to Receivables:
~
Debt Ratio:
3%
Final SIREN BIOTECH Independent CPA Audit Report 2024 and 2023.pdf Siren Biotechnology Inc. Unaudited Financial Stmts 12.31.25 Internal .xlsx Siren Biotechnology Inc GAAP Financial Report 2025.pdf
Management's Discussion and Analysis of Financial Condition and Results of Operations

You should read the following discussion and analysis of our financial condition and results of operations, together with our financial statements and the related notes included elsewhere in this report. This discussion contains forward-looking statements that involve risks and uncertainties. Actual results may differ materially from those described in these forward-looking statements.

Overview

Siren Biotechnology, Inc. was incorporated in Delaware in September 2020 and is a clinical-stage biotechnology company focused on developing AAV-based immuno-gene therapies for cancer. Since its inception, the Company has devoted substantially all of its resources to research and development, building its platform, and advancing its lead therapeutic candidate toward clinical trials.

During the past year, the Company achieved key milestones, including FDA acceptance of its IND for SRN-101, receipt of Fast Track designation for recurrent high-grade glioma, and continued expansion of its preclinical and translational research programs. The Company has also continued to strengthen its intellectual property portfolio and pursue non-dilutive funding opportunities.

Historical Results of Operations
  • Revenues & Gross Margin. For the period ended December 31, 2025, the Company had revenues of $0 compared to the year ended December 31, 2024, when the Company had revenues of $0.
  • Assets. As of December 31, 2025, the Company had total assets of $12,018,000, including $11,934,000 in cash. As of December 31, 2024, the Company had $17,539,808 in total assets, including $17,448,263 in cash.
  • Net Loss. The Company has had net losses of $10,884,000 and net losses of $4,666,672 for the fiscal years ended December 31, 2025, and December 31, 2024, respectively.
  • Liabilities. The Company's liabilities totaled $377,000 for the fiscal year ended December 31, 2025, and $784,882 for the fiscal year ended December 31, 2024.
Liquidity & Capital Resources

To date, the Company has financed its operations primarily through equity financings, including Seed, SAFE, Series A, and Regulation CF investments, as well as non-dilutive grant funding, including awards from the California Institute for Regenerative Medicine (CIRM) and many others.

As of early 2025, the Company had approximately $11.4 million in cash on hand. The Company’s historical operating expenses have averaged approximately $450,000 to $500,000 per month in recent periods. Based on current operating plans, the Company expects its existing cash resources to fund operations for a limited period and will require additional capital to support ongoing and future clinical development activities.

The Company intends to raise additional capital in the future through equity financings, strategic partnerships, or additional non-dilutive funding sources. However, there can be no assurance that such financing will be available on acceptable terms, or at all.

Results of Operations and Outlook


Operating expenses consist primarily of research and development costs, including preclinical studies, manufacturing, and preparation for clinical trials, as well as general and administrative expenses.

The Company does not expect to generate revenue in the near term, as its therapeutic candidates will require successful clinical development and regulatory approval prior to commercialization. The Company expects to continue incurring significant operating losses for the foreseeable future as it advances its programs through clinical development. The timing and amount of future capital requirements will depend on a number of factors, including the progress of clinical trials, regulatory timelines, manufacturing scale-up, and the ability to secure additional financing.

No Material Changes

There have been no material changes in the Company’s financial condition or results of operations since December 31, 2025, the date covered by the most recent financial statements. Operating expenses, burn rate, and overall financial position remain consistent with prior periods, and operations have continued in the ordinary course.

Forward-Looking Statements
All projections and statements contained in this section that are not historical facts are forward-looking statements and are subject to risks and uncertainties. Actual results may differ materially.

Risks

1
Our future success depends on securing the funding (investment, grants, licensing revenue, etc.) to advance our nonclinical, manufacturing, clinical, and regulatory development work to the point of commercialization or licensing of our therapies.
2
Our future success depends on the performance of vendors and partners to perform subcontracted nonclinical, manufacturing, clinical, regulatory, and intellectual property work.
3
Our future success depends on working within the guidelines of relevant federal regulatory agencies (e.g., the US FDA) to satisfy their current review procedures and approval processes.

Other Disclosures

The Board of Directors

Director Occupation Joined
Nicole K. Paulk CEO, Founder @ Siren Biotechnology, Inc. 2020
Sharon Tetlow CEO, Managing Partner @ Potrero Hill Advisors 2024
Stefano Gurciullo Managing Partner @ Tau Capital 2025

Officers

Officer Title Joined
Nicole K. Paulk Treasurer, Secretary, CEO, and President 2020

Voting Power

Holder Securities Held Power
Nicole K. Paulk 4,750,000 Class A common shares 89.1%

Past Fundraises

Date Security Amount
Priced Round $3,171,900
12/2024 Priced Round $18,799,263
11/2023 SAFE $2,436,204
9/2021 Priced Round $6,000,000

Outstanding Debts

None.

Related Party Transactions

None.

Use of Funds

$49,995 50% toward advancement of SRN-101, our lead AAV gene therapy, to the clinic. This includes nonclinical studies, drug product manufacturing, regulatory preparation, and clinical trial preparation.

45% towards operational expenses (headcount, payroll, rent, software).

5% towards Wefunder fees.

$4,999,995 50% toward advancement of SRN-101, our lead AAV gene therapy, to the clinic. This includes nonclinical studies, drug product manufacturing, regulatory consulting, and clinical trial preparation.

25% toward advancement of technological innovations that enable expansion to additional cancer types. This would include AAV engineering and nonclinical studies.

20% towards operational expenses (headcount, payroll, rent, software).

5% towards Wefunder fees.

Capital Structure

Class of Security Securities (or Amount) Authorized Securities (or Amount) Outstanding
Series Seed Preferred 2,375,010 2,375,010
Class A Common 4,750,000 4,750,000
Series A Preferred 5,155,485 4,041,110
Class B Common 14,401,000 133,436

Form C Filing on EDGAR

The Securities and Exchange Commission hosts the official Form C on their EDGAR web site.

Offering Updates

Siren Biotechnology raised 50% of their target offering amount on Jun 23 2025

Siren Biotechnology raised 100% of their target offering amount on Jun 23 2025

Details