Hi there 👋 I’m Dr. Nicole Paulk, Founder and CEO of Siren Biotechnology.

At Siren, we’re asking a wild question: What if a virus could treat cancer?

This isn’t science fiction. It’s the science we’re building.

We’re pioneering the world’s first off-the-shelf AAV gene therapy treatment designed to work for multiple cancers. For decades, new drugs have taken years to develop, cost billions, and often only treated one disease at a time. We’re changing that. 

🧬 How It Works: The Science Behind Siren

Our universal AAV immuno-gene therapy uses a safe, FDA-approved virus that doesn’t make people sick. We program it like software and design it to deliver natural immune-activating proteins directly into tumors. These proteins act like a fire alarm, alerting the immune system to destroy cancer cells while leaving healthy tissue untouched.

This is how our bodies already fight cancer every day. Siren is a powerful, targeted boost. 

🎯 Why We’re Starting with Brain Cancer

We’re going after one of medicine’s toughest challenges: brain cancer, a disease with unacceptably poor survival. Traditional treatments have failed for decades. But our data tells a different story.

In preclinical studies, we’ve eliminated human brain tumors in more than 550 animals, and we’re preparing for human clinical trials in 2026. A breakthrough here could unlock a new way to treat many types of cancer, with a platform that’s faster to develop, more affordable to produce, and more effective than anything that’s come before for these cancers.

🌍 The Impact

Siren is a breakthrough that could change the course of cancer treatment forever, turning a devastating diagnosis into a treatable condition and bringing real hope to millions of patients and families.

We’re radically rethinking the way we treat cancer, which touches all of us. We’ve opened a community investment round because we believe the future of medicine should be built by the people it protects. 

So we invite you to sound the alarm with us and join us in changing the future of cancer care.

🚨Invest or increase your investment today → 

With excitement,

Dr. Nicole K. Paulk, PhD

CEO, Founder, and President