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Phenomix Sciences

Mayo Clinic startup personalizing weight loss

What Investors Say


What Friends Say

Sean McCauley Investor
When I first heard that Andres was spinning out a company from his obesity research at Mayo, I was immediately on board to invest. I have known of his research personally and could not be more excited that this has finally reached a stage where it can be employed for patients beyond the walls of Mayo. From an opportunity perspective, the market is huge, but what is even more exciting is the potential impact this could have to thousands, if not millions of patients that are trying to lose weight.
Donna Ryan, MD Professor Emerita at Pennington Biomedical and President Elect of the World Obesity Federation
If we can prove that the Phenomix Sciences blood test predicts response and helps direct choice of treatment, it would be transformative. Our current "trial and error" method of selecting therapies is clunky, to say the least. Instead of guessing which drug to prescribe and waiting 3 months to see if it works, the provider would have the information at hand to rationally choose a therapy and know in advance that there was a high likelihood of response.

In the news

American Board of Obesity Medicine
October 30, 2018
A Conversation with Andres Acosta, MD, PHD Diplomate discusses "omics" abstract presented during Digestive Disease Week 2018 American Board of Obesity Medicine Diplomate Andres Acosta, M.D., PH.D., is hopeful that one day obesity can be treated with an approach that is individualized for each patient. A gastroenterologist and assistant professor of medicine at the Mayo Clinic in Rochester, MN, Dr. Acosta recently presented an abstract during Digestive Disease Week 2018 titled “Novel Multi-Omics, Blood-based Biomarker Predicts Obesity Phenotypes and Weight Loss to Obesity Therapy.” Dr. Acosta and co-authors addressed the obesity heterogeneity by classifying obesity into satiation, satiety (return to hunger), psychological and energy expenditure phenotypes, and identified a novel, first-of-its-kind, fasting, blood obesity test to diagnose the obesity phenotypes. The test includes obesity-associated genes variants, satiety peptides, and metabolites. When the test was applied to previously completed randomized clinical trials, the test improved weight loss response by ~60% to obesity pharmacotherapy. This novel multi-omic approach, driven by phenotypes, may be essential for reducing the variability and heterogeneity in obesity management.
October 29, 2018
Obesity: an individualized approach doubles the success rate of weight loss therapy
October 29, 2018
Many people think if they just stick to a diet and exercise, they'll lose weight; unfortunately, many are not successful. They wonder why they can't lose weight even after trying many different diets, work out programs and medications. According to Andres Acosta, M.D., Ph.D., the answers, at least partially, may be in your genes.
Expert Alert - Precision Medicine and Obesity
October 29, 2018
Newswise - ROCHESTER, Minn. - Mayo Clinic researchers have identified five sub-categories of obesity in an effort to determine the most effective, individual treatments. More than two in three adults are considered to be overweight or obese and 17 percent of children are obese in the United States.
Categories of obesity: Mayo Clinic Radio Health Minute
November 6, 2017
In this Mayo Clinic Radio Health Minute, Dr. Andres Acosta explains how categorizing obesity is helping to better understand the [...]
Genetics play a role in weight, but it's not the whole story
October 9, 2017
DEAR MAYO CLINIC: How big of a role does genetics play in weight? If you are predisposed to obesity because of your genes, how effective can a diet or other weight-loss strategies really be in the long run? Genetics play a role in determining your weight. But that's not the whole story.
Individualized Obesity Treatment: Mayo Clinic Radio
October 5, 2017
Dr. Andres Acosta, a gastroenterologist at Mayo Clinic, reviews a new, individualized approach to treating obesity through the Mayo Clinic Center for Individualized Medicine. This interview originally aired Sept. 2, 2017.
Obesity: An Individualized Approach Doubles The Success Rate Of Weight Loss Therapy
July 19, 2017
Many people think if they just stick to a diet and exercise, they'll lose weight; unfortunately, many are not successful. They wonder why they can't lose weight even after trying many different diets, work out programs and medications. According to Andres Acosta, M.D., Ph.D., the answers, at least partially, may be in your genes.
Disease drivers: Global consortia aim to unpack genetics of diabetes and obesity
August 4, 2016
Disease drivers: Global consortia aim to unpack genetics of diabetes and obesity
GI, psychological traits linked to obesity, predict response to weight-loss therapy
March 17, 2015
Quantitative gastrointestinal and psychological traits associated with obesity can differentiate between obesity phenotypes and predict response to weight-loss pharmacotherapy, according to recent study findings.Aiming to identify quantitative GI and psychological traits associated with obesity, and to validate the utility of these traits in predicting response to weight-loss drugs, Michael
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