A lengthy Final Four drought will end for one program on Saturday night when 1-seed Virginia (32–3) clashes with 3-seed Purdue (26–9) in the 2019 NCAA Tournament South Regional final in Louisville. Tipoff is at 8:49 p.m. ET.

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The Cavaliers are seeking their first Final Four appearance since 1984, while the Boilermakers haven’t reached the national semifinals since 1980. Virginia used its signature stifling defense to squeeze past Oregon 53–49 in the Sweet 16 on Thursday night.

Conversely, Purdue put on one of the most impressive offensive displays of the NCAA Tournament to knock off Tennessee 99–94 in overtime.

The Cavaliers are 4.5-point favorites and the over-under for total points scored is 126 in the latest Virginia vs. Purdue odds. Before you lock in your Virginia vs. Purdue picks and 2019 NCAA Tournament Elite 8 predictions, check out what the SportsLine Projection Model has to say.

SportsLine Projection Model has returned more than $4,000 to $100 players on its top-rated college basketball picks and entered the postseason on a strong 11–5 run on all top-rated college basketball plays.

It’s also on fire in the 2019 NCAA Tournament, calling 14 of the Sweet 16 teams straight-up. Anyone who has followed it is way up.

Now the model has dialed in on Virginia vs. Purdue. We can tell you it is leaning over, and it has a strong against-the-spread pick that hits in well over 50 percent of simulations. That pick is only available at SportsLine.

The model knows Virginia is hungry to reach its first Final Four under coach Tony Bennett. The accomplishment would serve as the ultimate comeback after last year’s postseason in which Virginia became the first 1-seed ever to fall to a 16-seed.