{"data":{"type":"company_profile_ai","id":180166,"entity_id":"wefunder:company:180166","attributes":{"canonical_url":"https://wefunder.com/frontier.bio","retrieval_urls":{"canonical":"https://wefunder.com/frontier.bio","json":"https://wefunder.com/frontier.bio.json","markdown":"https://wefunder.com/frontier.bio.md","ai_json":"https://wefunder.com/frontier.bio.ai.json","ai_text":"https://wefunder.com/frontier.bio.ai.txt","changelog_json":"https://wefunder.com/frontier.bio.changelog.json","schema":"https://wefunder.com/.well-known/ai-profile-schema.json"},"updated_at":"2026-06-06T05:02:25Z","generated_at":"2026-06-06T22:36:49Z","profile_visibility":{"owner_published":true,"public_search_results":true,"site_search_listed":true,"privacy_mode":"promote","invite_only":false},"company":{"id":180166,"entity_id":"wefunder:company:180166","slug":"frontier.bio","name":"Frontier Bio","tagline":"Our Mission: End the Organ Shortage \u0026 Replace Animal Testing","location":"Hayward, CA","website":"https://www.frontierbio.com","total_amount_raised":402656,"total_investors":332,"is_funded":true,"is_active":true},"key_claims":[{"claim_id":"claim-total-raised","text":"Total raised on Wefunder: 402656","citation":"https://wefunder.com/frontier.bio#claim-total-raised","provenance":{"source":"FrontCompanySummary#amount_raised","last_verified_at":"2026-06-06T05:02:25Z","as_of":"2026-06-06T22:36:49Z","confidence":"high"},"observed_at":"2026-06-06T05:02:25Z","expires_at":"2026-06-07T05:02:25Z"},{"claim_id":"claim-total-investors","text":"Total investors: 332","citation":"https://wefunder.com/frontier.bio#claim-total-investors","provenance":{"source":"FrontCompanySummary#number_of_investors","last_verified_at":"2026-06-06T05:02:25Z","as_of":"2026-06-06T22:36:49Z","confidence":"high"},"observed_at":"2026-06-06T05:02:25Z","expires_at":"2026-06-07T05:02:25Z"}],"verified_facts":[{"claim_id":"claim-total-raised","text":"Total raised on Wefunder: 402656","citation":"https://wefunder.com/frontier.bio#claim-total-raised","provenance":{"source":"FrontCompanySummary#amount_raised","last_verified_at":"2026-06-06T05:02:25Z","as_of":"2026-06-06T22:36:49Z","confidence":"high"},"observed_at":"2026-06-06T05:02:25Z","expires_at":"2026-06-07T05:02:25Z"},{"claim_id":"claim-total-investors","text":"Total investors: 332","citation":"https://wefunder.com/frontier.bio#claim-total-investors","provenance":{"source":"FrontCompanySummary#number_of_investors","last_verified_at":"2026-06-06T05:02:25Z","as_of":"2026-06-06T22:36:49Z","confidence":"high"},"observed_at":"2026-06-06T05:02:25Z","expires_at":"2026-06-07T05:02:25Z"}],"company_claims":{"tagline":"Our Mission: End the Organ Shortage \u0026 Replace Animal Testing","story":"Our mission is to eliminate the organ transplant waitlist and replace animal studies. While many biotech companies remain in the lab for years, Frontier Bio is generating revenue today. We have generated $5.5M in cumulative sales by starting with products and services that researchers need now while advancing toward implantable tissues for patients.1. Demonstrated Commercial TractionOur business is built on human tissue models for preclinical testing. These living tissues allow our partners to generate human-relevant data early in development, reducing their reliance on often-inaccurate animal models. We currently serve customers ranging from cell therapy innovators to government, helping them study disease and validate how novel therapies interact with human biology.2. Advancing Toward the ClinicWe are applying our tissue engineering expertise to our first implantable product: a living, tissue-engineered vascular graft. Cardiovascular disease is the leading cause of death worldwide1World Health Organization. (2025,\u0026nbsp;July 31).\u0026nbsp;Cardiovascular diseases (CVDs). WHO.\u0026nbsp;https://www.who.int/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds), creating a great need for replacement blood vessels to use as vascular grafts. Unlike synthetic implants that can often fail, our grafts are designed to remodel into a natural, living blood vessel within the patient’s body.3. Long-Term VisionBlood vessels are the essential infrastructure of life. By advancing lab-grown tissues for testing and vascular grafts for implantation, we aim to build the biological foundation that could support future regenerative medicine applications, including transplantable organs.These statements contain forward-looking information based on current expectations and assumptions. Actual results may differ materially due to risks and uncertainties. No assurance can be given that projected outcomes will be achieved. Investing involves risk, including possible loss of principal.The ProblemFrom the lab to the operating room, medicine faces ongoing shortages of functional human tissue for research, vascular repair, and organ transplantation.Pharmaceutical companies still rely heavily on animal testing to evaluate new therapies. These models can be expensive and time-consuming, and translating findings from animal studies to human biology remains complex. About 90 percent of drugs that pass animal studies fail in human trials.2doi: 10.1016/j.jacbts.2019.10.008, doi: 10.1039/c8lc00330k, doi: 10.1038/nrd4539 Regulatory agencies and research institutions are increasingly exploring human-based systems, but better tools are needed to make that transition practical.In clinical settings, synthetic vascular grafts remain standard for various procedures. These grafts do not biologically integrate with the body and tend to fail in small-diameter vessel applications. Failure rates can reach 65% within two years, leading to additional surgeries, higher costs, and worse outcomes for patients. A potentially ideal solution is a “living scaffold” that transforms into native tissue over time.(source)The shortage of human tissue affects millions of patients. More than 100,000 people in the U.S. wait for organ transplants. Hundreds of thousands more need vascular grafts for surgery each year. Current solutions rely on synthetic materials that fail or on donor tissue, which is in limited supply. The shortage continues to widen as demand outpaces what's available. New strategies are needed to create functional, living human tissue.Our SolutionWe leverage deep expertise in human tissue engineering to address two significant healthcare challenges.To improve the accuracy of preclinical testing, we create lab-grown human tissue models designed to serve as high-fidelity alternatives to animal studies.High-Fidelity: Our models are engineered to reproduce selected biological functions of the brain, lungs, and blood vessels, providing a human-relevant platform for evaluating safety and biological activity.Commercial Application: These systems are designed to support the evaluation of a range of therapeutic approaches, from pharmaceutical drugs to novel cell therapies. We are currently collaborating with partners to use these models to support the development of next-generation therapies.We are developing a regenerative graft designed to use the patient’s own stem cells to address the high failure rate of purely synthetic grafts.Seeded at the Bedside, Grown in the Body: By combining the patient’s own cells with a bioresorbable scaffold at the bedside, we aim to mitigate the risk of immune rejection and the need for vein harvesting. The result is a graft that is engineered to transform into a natural blood vessel over time after implantation, designed to provide a long-term solution that overcomes the limitations of purely synthetic materials.Target Applications: We are focusing on critical procedures where current options fall short, including dialysis access (AV access), coronary artery bypass, peripheral artery bypass, and trauma repair.Immediate \u0026amp; Regenerative: The graft is engineered to conduct blood flow immediately upon implantation. With this design, over time, the biodegradable scaffold is absorbed and replaced by living tissue to create a durable vessel that integrates naturally designed to minimize the risk of long-term foreign body rejection.The Path to Engineered OrgansBlood vessels are the foundation of every organ. Developing functional vascular tissue now lays the groundwork for full organ engineering. This core capability positions us to address transplantable tissues and organs such as pancreas, lung, kidney, liver, and heart.The same biological expertise that powers our human tissue models today forms the foundation for our mission to develop tissue-engineered blood vessels and eventually pioneer lab-grown organs.MarketFrontier Bio operates in two evolving sectors that are shifting away from synthetic and animal-based models toward human tissue engineering.Human Tissue Models - An Animal AlternativeThe global market for human tissue models is estimated at approximately $2.1 billion3Ghosh, S. (2026, January 15). In-vitro human models market size and share forecast outlook 2026 to 2036. Future Market Insights. Retrieved February 22, 2026, from https://www.futuremarketinsights.com/reports/in-vitro-human-models-market and continues to grow as researchers explore alternative approaches to traditional animal studies. We believe our platform is well positioned to participate in this evolving market as regulatory agencies and research institutions evaluate and expand the use of human-based research tools.Vascular GraftsThe vascular graft market is massive but severely underserved. For small vessels, surgeons are currently forced to choose between two flawed options: synthetic grafts with significant failure rates, or harvesting the patient’s own vein, which prolongs surgery and causes donor-site injury.4Pashneh-Tala S, MacNeil S, Claeyssens F. The Tissue-Engineered Vascular Graft-Past, Present, and Future. Tissue Eng Part B Rev. 2016 Feb;22(1):68-100. doi: 10.1089/ten.teb.2015.0100. Epub 2015 Oct 8. PMID: 26447530; PMCID: PMC4753638. [973 citations via Google Scholar, retrieved February 2026]We are developing a solution to address these shortcomings. Our approach combines the patient’s own stem cells with a bioresorbable scaffold, designed to transform into a living vessel inside the body.5Allon M, Zhang Y, Thamer M, Crews DC, Lee T. Trends in vascular access among patients initiating hemodialysis in the United States. JAMA Netw Open. 2023;6(8):e2326458. Al‑Balas A, Lee T, Young CJ, Allon M. Choice of a second vascular access in hemodialysis patients whose initial arteriovenous fistula failed to mature. J Vasc Surg. 2018;68:1858‑64.e1. doi:10.1016/j.jvs.2018.03.419. Dahlerus C, Kim S, Chen S, Segal JH. Arteriovenous fistula use in the United States and dialysis facility‑level comorbidity burden. Am J Kidney Dis. 2020;75:879‑86. doi:10.1053/j.ajkd.2019.08.023. United States Renal Data System. Vascular access [Internet]. 2024 USRDS Annual Data Report. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2024 [cited 2025 Jul 4]. Available from: https://usrds-adr.niddk.nih.gov/2024/end-stage-renal disease/4-vascular-access https://doi.org/10.1089/ten.teb.2015.010Towards Lab-Grown Implantable OrgansAccording to the World Health Organization, only 10% of global organ demand is met. This scarcity, combined with lifetime care costs that can exceed $1M per patient, has created a $100B+ market opportunity.6Yadav U. Global regenerative medicine market size, industry analysis and outlook (2025-2033) [Internet]. DataM Intelligence; 2026 Feb 3 [cited 2026 Feb 22]. Available from: https://www.datamintelligence.com/research-report/regenerative-medicine-marketFor example, the demand for lung transplants is incredibly high, yet they come at a substantial cost.7Thabut G, Mal H. Outcomes after lung transplantation. J Thorac Dis. 2017 Aug;9(8):2684-2691. doi: 10.21037/jtd.2017.07.85. PMID: 28932576; PMCID: PMC5594127. Ortner N, Holzer H. 2025 U.S. organ and tissue transplants: Estimated costs and utilization, emerging issues, and solutions. Milliman. 2025 Feb 13 [cited 2026 Feb 22]. Available from: https://www.milliman.com/en/insight/2025-us-organ-and-tissue-transplants-costs-utilization TractionRevenue-First Biotech ModelUnlike many preclinical biotechs, we are already generating revenue. We use sales from our commercial tissue models to fund and support our clinical endeavors.World-Class Partners \u0026amp; Customer AdoptionTop-tier institutions rely on our tissue models to test therapies and study disease.Clinical Progress: Road to the ClinicOur vascular graft program is advancing toward human trials. We have engaged the FDA early to help clarify our path to market.Elite Scientific Backing \u0026amp; Commercial ValidationWe are built on elite scientific backing, a defensive IP moat, and disciplined capital execution.Strategic Consortia \u0026amp; Accelerator ParticipationFrontier Bio participates in established defense, manufacturing, and innovation ecosystems that support collaboration, early commercialization efforts, and manufacturing readiness in regenerative medicine, including MTEC, ARMI, StartX, Alchemist Accelerator, Brinc, and the NSF SBIR Beat-the-Odds Bootcamp.How We Make MoneyOur business model leverages our deep expertise in tissue engineering and stem cells to drive near-term and long-term revenue streams. We generate revenue today through our existing capabilities while continuing to invest in future clinical development programs.The Growth Engine: Human Tissue Sales \u0026amp; ServicesWe generate revenue by providing high-fidelity human tissue models and tissue R\u0026amp;D services to commercial partners, academic institutions, and the government.Customer Base: We serve companies, universities, and government who are developing therapeutics, studying disease, and advancing medical science.High-Value Contracts: Our clients pay for tissues and bespoke R\u0026amp;D. We have secured sizable contracts for our various tissues ranging from $250k up to $1.1M.Strategic Expansion: Our sales strategy focuses on executing successful pilot projects, with the goal of transitioning those early engagements into broader, long-term research partnerships.Beachhead Clinical Market: Vascular Grafts (in development)Our clinical vertical will focus on the sale of our tissue-engineered vascular graft.Model: Direct sales to hospitals and surgical centers for use in operating rooms.Beachhead Application: Vascular access for dialysis. This is a critical clinical need with established reimbursement pathways and a defined regulatory framework.Expansion: While advancing dialysis grafts, we aim to generate validation data for other applications such as trauma, coronary artery bypass, and peripheral artery disease (PAD) bypass to address a significantly larger total market.Use of FundsWe are raising on Wefunder to advance preclinical testing of our vascular grafts, scale customer acquisition for our tissue models, and expand commercial and government partnerships.*Allocation may change depending on regulatory or operational needs.The statements above reflect the personal views and opinions of the individuals quoted and are based on their experience with Frontier Bio. These statements do not constitute an endorsement of the Company or its securities offering. No compensation was provided for these testimonials. Past performance and investor opinions are not indicative of future results.Help Us Build a Future Without the Organ Waitlist \u0026amp; Reduce Animal TestingDeep technology can take years to move from the lab to real-world application. We are already generating revenue in the market.Our tissue models are currently generating revenue and represent a small step towards the long term goal of drastically reducing the industry's reliance on animal testing. We are now advancing our development of implantable tissue technologies towards future clinical use.We have the traction, the team, and the technology. Now we need you.Help us develop technologies to save patients, spare animals, and engineer the future of human tissue.This is a Regulation Crowdfunding offering. Investing in early-stage biotech carries risk, including total loss of capital. FDA approval is not guaranteed. Please review all offering materials and risk factors before investing.","quick_facts":["$5.5M in Cumulative Sales: Validated demand from customers for tissue models built with human cells.","Transforming Medicine: Reducing animal studies and advancing implantable human tissue.","Market Opportunity: Multi-billion-dollar market for human tissue models and vascular grafts","$4.1M Raised to Date: Strong investor confidence with $1.6M committed in the current round.","Patent Families: Defensible IP covering core tissue biofabrication and vascular graft technologies.","Elite Backing \u0026amp; Support: Funded by NSF SBIR and a Nobel Laureate, and advised by George Church.","Trusted by Industry Leaders: Clients include Mayo Clinic and Intuitive Surgical."]},"computed_metrics":{"total_amount_raised":402656,"total_investors":332,"team_size":7,"featured_investor_count":1,"faq_count":5,"recent_post_count":0},"quick_facts":[{"claim_id":"claim-fact-1","value":"$5.5M in Cumulative Sales: Validated demand from customers for tissue models built with human cells.","citation":"https://wefunder.com/frontier.bio#claim-fact-1","observed_at":"2026-06-06T05:02:25Z","expires_at":"2026-06-13T05:02:25Z"},{"claim_id":"claim-fact-2","value":"Transforming Medicine: Reducing animal studies and advancing implantable human tissue.","citation":"https://wefunder.com/frontier.bio#claim-fact-2","observed_at":"2026-06-06T05:02:25Z","expires_at":"2026-06-13T05:02:25Z"},{"claim_id":"claim-fact-3","value":"Market Opportunity: Multi-billion-dollar market for human tissue models and vascular grafts","citation":"https://wefunder.com/frontier.bio#claim-fact-3","observed_at":"2026-06-06T05:02:25Z","expires_at":"2026-06-13T05:02:25Z"},{"claim_id":"claim-fact-4","value":"$4.1M Raised to Date: Strong investor confidence with $1.6M committed in the current round.","citation":"https://wefunder.com/frontier.bio#claim-fact-4","observed_at":"2026-06-06T05:02:25Z","expires_at":"2026-06-13T05:02:25Z"},{"claim_id":"claim-fact-5","value":"Patent Families: Defensible IP covering core tissue biofabrication and vascular graft technologies.","citation":"https://wefunder.com/frontier.bio#claim-fact-5","observed_at":"2026-06-06T05:02:25Z","expires_at":"2026-06-13T05:02:25Z"},{"claim_id":"claim-fact-6","value":"Elite Backing \u0026amp; Support: Funded by NSF SBIR and a Nobel Laureate, and advised by George Church.","citation":"https://wefunder.com/frontier.bio#claim-fact-6","observed_at":"2026-06-06T05:02:25Z","expires_at":"2026-06-13T05:02:25Z"},{"claim_id":"claim-fact-7","value":"Trusted by Industry Leaders: Clients include Mayo Clinic and Intuitive Surgical.","citation":"https://wefunder.com/frontier.bio#claim-fact-7","observed_at":"2026-06-06T05:02:25Z","expires_at":"2026-06-13T05:02:25Z"}],"latest_fundraise":{"id":157134,"entity_id":"wefunder:fundraise:157134","state":"successful","offering_type":"4(a)(6)","structure":"ttw","testing_the_waters":true,"can_invest_now":false,"funding_started_at":null,"funding_closed_at":null},"investor_memos":[],"team":[{"id":5666172,"entity_id":"wefunder:company_role:5666172","name":"Eric Bennett, MSc","title":"CEO","role":"founder","profile_url":"https://wefunder.com/ericbennett"},{"id":6590385,"entity_id":"wefunder:company_role:6590385","name":"Dr. Sam Pashneh-Tala, PhD","title":"CTO","role":"founder","profile_url":"https://wefunder.com/sam.pashnehtala"},{"id":6597899,"entity_id":"wefunder:company_role:6597899","name":"Dr. George M. 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With a sales track record that speaks for itself, having secured contracts with Intuitive Surgical and Mayo Clinic, the team has proven they can deliver. 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(I acknowledge that this is far in...","answer":"Thank you Jason - I will answer these one at a time. Question 1: What do you foresee as the potential legal/FDA barriers or steps to using lab grown human tissues for medical testing if you went to full human organs as opposed to blood vessels? It helps to look at this from two angles: testing and clinical implantation. For testing (of therapeutics / drugs / disease modeling), we actually do not need to grow a full-sized organ. We use micro-tissues and small \"organ-on-a-chip\" devices (populat..."},{"question":"Hello, very impressive progress so far! Two questions, I wondered if you could speak to the strategy of crowdfunding as opposed to additional VC funding. I am sure some would be interested even at this early stage is why I ask. Second, any guidance on full year 2025 loss? Look...","answer":"Thanks for asking about our funding strategy! Committing to the traditional venture route today often means sacrificing over a year to investor roadshows and exhausting diligence. We simply cannot afford to have our leadership sidelined for 12 months. Regulation Crowdfunding empowers us to control our capital pipeline directly, keeping our executive focus exactly where it belongs: on growing the business and executing our core mission. Beyond the time savings, choosing crowdfunding allows us ..."},{"question":"Hi Eric, I see that the company has been around since 2018, why is now the time to invest? What has changed in the recent years? Thank you, Glenn","answer":"Thanks for the great question! We have been building our foundational technology since 2018, but the industry landscape and our own momentum have completely shifted recently. Here is why right now is the perfect time to invest: First, both the FDA and the NIH have announced major shifts away from animal testing. This is driven by the FDA Modernization Act 2.0, which explicitly authorizes alternatives. This historic legislation directly accelerates the commercial demand for our lab-grown tissu..."},{"question":"what kind of competition does Lung Biotechnology PBC offer for your long term prospects?","answer":"Thank you for the excellent question. Lung Biotechnology PBC and their parent company United Therapeutics are doing incredible work. I'd say their most impressive work is with their xenotransplantation approach, which relies on genetically modified pig organs. While they are a pioneer in the space, we believe our autologous biofabrication approach provides the ultimate long-term solution. In fact, because they are investing so heavily in organ manufacturing, we view large players like them as..."},{"question":"As a critical care PA in the CTICU, I am very familiar with these patients and procedures. I love the direction of the company. For bypass surgery specifically, I know the pain points of vein harvesting, and recovery from that. It is complex physiology, but if you are able to ...","answer":"Thank you for your interest! Hearing this from someone on the front lines in the CTICU is incredible validation. You know exactly why we are aiming to eliminate the painful reality of vein harvesting. With our tissue-engineered vascular graft, we hope to change the standard of care for these complex patients, and we would be honored to have someone with your clinical expertise join us as an investor."}],"recent_posts":[],"provenance":{"source":"wefunder_public_company_profile","as_of":"2026-06-06T22:36:49Z","claims":{"total_amount_raised":{"source":"FrontCompanySummary#amount_raised","last_verified_at":"2026-06-06T05:02:25Z","as_of":"2026-06-06T22:36:49Z","confidence":"high"},"total_investors":{"source":"FrontCompanySummary#number_of_investors","last_verified_at":"2026-06-06T05:02:25Z","as_of":"2026-06-06T22:36:49Z","confidence":"high"},"active_raise_states":{"source":"Fundraise.visible(nil, nil)","last_verified_at":"2026-05-01T05:07:38Z","as_of":"2026-06-06T22:36:49Z","confidence":"high"},"latest_fundraise_state":{"source":"Fundraise.visible(nil, nil).order(funding_started_at)","last_verified_at":"2026-05-01T05:07:38Z","as_of":"2026-06-06T22:36:49Z","confidence":"medium"}}}}}}