# Critical comparison of optimal flu vaccine modality | InvVax

- Canonical URL: https://wefunder.com/feed/171398
- Entity ID: wefunder:feed_item:171398
- Published at: 2024-03-08 22:30:42 UTC
- Updated at: 2025-07-09 03:24:35 UTC

## Author
Arthur Young

## Subject
InvVax

## Content
Greetings everyone,We're happy to say that our pivotal flu vaccine mouse study with Duke University is underway! Funded by an NIH grant through the Duke CIVICs program (Collaborative Influenza Vaccine Innovation Centers), we're comparing our adenoviral-vectored flu vaccine, already proven to work well, to mRNA as well as to peptides. As you almost certainly know, mRNA was the difference-maker that got the COVID-19 vaccine into clinics and played a major role in ending the pandemic. Many companies and labs worldwide have turned to mRNA to vector their vaccines for other pathogens, flu and HIV included. We took up adenovirus several years before the COVID-19 pandemic, and while it works well in mice, there are a few drawbacks. For example, many people have antibodies to adenovirus, and these have the potential to reduce the efficacy of the vaccine. We've utilized two vendors, Trilink Biosciences to make our mRNA, and Precision Nanosystems to make our lipid nanoparticles (chemicals which facilitate the uptake of mRNA into cells). Duke U, led by Dr. Herman Staats, initiated the experiment a little over a month ago. So far the mice have gotten their prime as well as their boost of mRNA. Other groups are getting the adeno via different routes: intranasal, intramuscular, and intranasal + subcutaneous (which we've proven to work). Still another group has gotten peptides (fragments of proteins). We'll know the definitive outcome in about two months. However this plays out we'll be in a much stronger position to forge a partnership with Big Pharma (we've already seen interest by some of them in this experiment). This experiment, along with just one more we have planned with Duke, represent the final preclinical efficacy studies before we're ready to kick off regulated manufacturing for clinical trials.Stay tuned! And as always, if you'd like to invest, the link is here:https://wefunder.com/invvax/ask