# Factors Affecting Osteoporosis  | OsNovum

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- Entity ID: wefunder:feed_item:141221
- Published at: 2021-01-19 21:28:01 UTC
- Updated at: 2025-07-09 03:19:36 UTC

## Author
Gregory Steiner

## Subject
OsNovum

## Content
Osteoporosis is like many of our chronic diseases of aging. Osteoporosis is associated with systemic inflammation. We know that an inflammatory environment stimulates osteoclasts to proliferate and remove bone and it stops osteoblasts from forming bone. However, this inflammation is not what we recognize as inflammation. There is no redness or swelling. The inflammation is characterized by circulating inflammatory molecules or inflammatory bacteria. You cannot look at the tissue to see the inflammation. However, the circulating inflammatory molecules stimulate many responses in the body that lead to disease such as osteoporosis and atherosclerosis (heart disease). Systemic inflammation is a common precipitating factor in the diseases of aging, but we do not need to helplessly accept systemic inflammation and the damage it causes. In recent years we have begun to understand a primary source of inflammation and the story begins in the gut. The gut contains many good and bad bacteria. In youth, that bacteria are isolated from gaining access to the body through a well-sealed gut lining. However, as we age that changes. Post-menopausal women suffer from a large increase is bone loss and the development of osteoporosis. Estrogen has ben found to be critical in maintaining the tight junctions that seal the gut. During menopause, when estrogen concentration drops, the tight junctions in the gut begin to fail and inflammatory molecules leach into the blood stream including the possibility of whole bacterial. This breach of the gut lining leads to systemic inflammation and osteoporosis. Men derive the estrogen in a metabolic byproduct of the breakdown of testosterone. Men also suffer a rise in systemic inflammation but is slower and much less dramatic as their testosterone levels decrease during aging. Should we accept this inflammatory process.? No! Brilliant research is giving us some simple tools to combat it. Recent findings have reported that in post-menopausal mice that normally develop osteoporosis, can be prevented by the administration of the probiotic L. reuteri. This is not a common probiotic. The more common strains of probiotics were found to be ineffective. We have convincing evidence that osteoporosis can be prevented by modifying the gut bacteria in mice. IT has not been proven to date in humans but when I see therapy that can be a very valuable asset to my patients, and I know there are no downsides to administering the therapy I choose not to wait another 10 yeas for the studies to be done in humans. I have found a source of L. reuteri that I trust. The product is a combination of L. reuteri and vitamin D and is called Bio Gaia Osfortis. It is marketed as a probiotic for women but that is for marketing purposes because men benefit just a well. I recommend it for both men and women. We are learning about the serious systemic diseases that are developing because of having the wrong bacteria in our guts. For this reason, when I prescribe antibiotics that will disrupt the gut bacteria, I also prescribe Bio Gaia Osfortis to take for a month following antibiotic therapy. Next post will report on recent findings that are found in bone aging and it effects on the development of osteoporosis and how the regenerative therapy provided by OsNovum can reverse the aging process found in bone.